Oxytocin analogues have potential in relieving chronic abdominal pain
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چکیده
منابع مشابه
Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain.
Poor oral availability and susceptibility to reduction and protease degradation is a major hurdle in peptide drug development. However, drugable receptors in the gut present an attractive niche for peptide therapeutics. Here we demonstrate, in a mouse model of chronic abdominal pain, that oxytocin receptors are significantly upregulated in nociceptors innervating the colon. Correspondingly, we ...
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Accepted 20 March 1997 A 55-year-old man presented with a two-year history of post-prandial epigastric pain and 10 kg weight loss. He smoked 20 cigarettes per day and suffered intermnittent claudication. Physical examination revealed bilateral absence of dorsalis pedis and anterior tibial arterial pulsation. His symptoms continued for a further two years and his weight fell by a further 3 kg. O...
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Marked peritoneal thickening extending into the mesentery can occur with malignant infiltration but is usually very nodular and distributed irregularly. Pseudomyxoma peritonei can produce diffuse generalized infiltration in the mesentery and surrounding the liver and spleen, but on CT has a low attenuation similar to ascites. Tuberculous peritonitis classically produces generalized, diffuse per...
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ژورنال
عنوان ژورنال: Nature Reviews Gastroenterology & Hepatology
سال: 2014
ISSN: 1759-5045,1759-5053
DOI: 10.1038/nrgastro.2014.20